Active ingredients of the herb decrease Apo proteins synthesis required for structural existence of LDL Particles
Dr. Shah Murad Mastoi, Shahina, Hina Aslam, Khalid Niaz, M Ashraf Memon and Abdul Ghaffar
Introduction: Hyperglycemia and hyperlipidemia are main risk factors for coronary artery disease like syndrome leading to morbidity, and mortality. This syndrome may be prevented by allopathic as well as herbal medicines like Nigella sativa and fibrates. Conventional allopathy related drugs have unwanted effects. Herbal therapy for hyperlipidemia well as diabetes mellitus type-2 (DMT2) is getting attention due to their less frequent side effects. In this study we have compared hypolipidemic effects of Fenofibrate 40 mg with Nigella sativa.
Sample size and study area: Seventy five hyperlipidemic and DM type-2 patients from National Hospital Lahore were enrolled for study.
Consent, grouping in sample size and Advise to patients: After getting consent all patients were divided in three groups comprising 25 patients in each group. Group 1 was on Nigella sativa, group 2 was on Gemfibrozil 600 mg BD plus Glibenclamide 5 mg BD and third group was on placebo therapy. They were advised to take drugs for two months.
Results: After completion of study pretreatment and post treatment values of LDL cholesterol were analyzed statistically. In Nigella sativa group LDL cholesterol decreased from 191.14±3.45 to 159.40±2.98 mg/dl, means 31.7 mg/dl LDL reduction was observed when compared with placebo group. Fasting Blood Sugar (FBS) in this group decreased from 210 mg/dl to 180 mg/dl in two months which is significant change in this parameter. In Fenofibrate group of patients LDL cholesterol decreased from 197.77±3.91 mg/dl to 159.62±2.20 mg/dl, means LDL reduction in mean values was 38.2 mg/dl, when compared with placebo group. These changes are highly significant with p-values of <0.001. FBS in this group decreased from 219.65±1.10 to 171.76±2.04 mg/dl which is highly significant change in the parameter.
Conclusion: We concluded from this study that herbal medicine Nigella sativa is as effective hypoglycemic/hypolipidemic agent as traditionally used hypolipidemic drug Fenofibrate, and hypoglycemic drug Glibenclamide.
Dr. Shah Murad Mastoi, Shahina, Hina Aslam, Khalid Niaz, M Ashraf Memon, Abdul Ghaffar. Active ingredients of the herb decrease Apo proteins synthesis required for structural existence of LDL Particles. Int J Res Hum Resour Manage 2019;1(2):11-13.